Guide

Researchers at the Royal Melbourne Institute of Technology (RMIT) have developed a gas-capable capsule that can be swallowed. The first human trial results of the capsule are expected to revolutionize the prevention and diagnosis of intestinal diseases.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Albert Swiston / MIT Lincoln Laboratory)

A new battery powered by stomach acid: it can power small medical sensors or drug delivery devices and can reside in the intestines for long periods of time.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Massachusetts Institute of Technology)

A flexible sensor that can be rolled up and swallowed: it can adhere to the stomach wall and the intestinal wall after being ingested by the human body to measure the rhythmic contraction of the digestive tract.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Massachusetts Institute of Technology)

Miniature origami robot: Opens from a swallowable capsule and is controlled by an external magnetic field to crawl on the stomach wall to remove accidentally swallowed button cells or repair wounds.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Melanie Gonick/MIT)

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Peter Clarke/RMIT University)

technology

This ingestible capsule (sized like a vitamin pill) is able to detect intestinal gases in real time: hydrogen, carbon dioxide, oxygen, and send this data to the phone.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

(Source: Reference [2])

Research team leader and capsule inventor Professor Kourosh Kalantar-zadeh said the trial showed that the body's stomach uses an oxidant to fight foreign objects in the gut.

Capsule sensor that can be swallowed: is expected to completely change the prevention and diagnosis of intestinal diseases

The test also showed that capsules provide a more effective way to measure microbial activity in the stomach, which is an important way to judge the health of the intestines.

Kalantar-zadeh said: “Before, we had to rely on stool samples or surgery to sample and analyze the microbes in the gut. But this means that when measuring them, they do not really reflect intestinal microbial activity. And our capsules It provides a non-invasive method for the measurement of microbial activity."

Now that the capsule has successfully passed human trials, the research team is looking to commercialize the technology.

Co-inventor Dr. Kyle Berean said: "These trials show that the capsules are completely safe and have no retention. Our ingestible sensors provide a potential diagnostic tool for many intestinal diseases ranging from malnutrition to intestinal cancer. This is a The good news is that many people will choose to use intrusive operations in the future. We have worked with Planet Innovation and founded a company called 'Atmo Biosiences' to bring products to market. This will lead to the second phase of human trials, and Helping to raise funds to distribute this safe and revolutionary gut monitoring and diagnostic device to patients and medical professionals."

value

This new technology and new discoveries will change the rules of the game for one-fifth of the world's population, who have suffered from gastrointestinal illnesses during their lifetime. At the same time, this new technology will also reduce the use of invasive procedures such as colonoscopy.

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